Il ne s'agit pas d'une découverte majeure. Mais elle est, selon les mots du professeur Hervé Fleury, chef du service de virologie au CHU de Bordeaux, « intéressante ». Ce cas est en fait déjà connu de spécialistes comme ce médecin bordelais comme celui de « l'homme de Berlin ». Tout simplement parce qu'il a été soigné dans un hôpital de la capitale allemande.
Célèbre depuis hier, il date en réalité de l'année 2007. Il a été présenté depuis lors de colloques scientifiques et dans la revue « Blood » assez récemment. Cet homme de Berlin est un patient américain de 40 ans résidant en Allemagne et atteint du sida. Il y a été traité par le docteur Gero Hütter, de l'hôpital universitaire de la Charité à Berlin, pour une leucémie, un cancer du système immunitaire. Le patient a été soumis à un traitement de choc : une chimiothérapie et une radiothérapie pour supprimer entièrement ses cellules immunitaires défaillantes. Puis il a subi une greffe de moelle osseuse, destinée à produire de nouvelles cellules immunitaires saines.
De nouvelles cellules
Dans le protocole du traitement de son cancer, il était prévu qu'il cesse de prendre ses antirétroviraux pour ne pas nuire au succès de l'opération. Ces derniers permettent pourtant de maintenir à un niveau très bas la présence du virus du sida. Ce patient américain se retrouvait ainsi sans protection contre le VIH, mais avec de toutes nouvelles cellules de défense grâce à la greffe. Et tout l'intérêt de ce cas de « l'homme de Berlin » est que le virus du sida semble avoir totalement disparu. Il est en tous les cas indétectable - depuis 2007, année de la greffe de moelle osseuse - par les moyens connus.
Une situation assez exceptionnelle, au moins pour sa persistance dans le temps et le suivi très précis de ce cas. Il faut toutefois relativiser cette guérison. Surtout parce que ce patient a reçu la moelle d'un donneur très particulier. Ce dernier est porteur d'une mutation génétique rare qui rend ses cellules immunitaires résistantes aux principales formes de VIH. On estime que 1 % de la population est porteuse de ce gène muté appelé CCR5. Grâce à cela, le virus du sida ne peut plus s'accrocher aux cellules, pour simplifier.
Cette greffe très particulière relativise évidemment la portée de cette guérison. « Dans les faits, très peu de malades du sida pourraient en profiter. D'autant que cette technique de greffe est très lourde, et très rarement utilisée », indique le professeur Fleury. Par ailleurs, le fait que le virus ne soit pas réapparu maintenant ne signifie pas qu'il ne reviendra pas dans le corps du patient. « On pense que le virus a disparu. Mais ce n'est pas une certitude, tempère le scientifique. Il a tout de même des réservoirs profonds dans certaines zones. Plus le temps passe, plus on peut être optimiste, c'est certain. Mais rien ne dit que le sida ne va pas se redéclencher dans trois ou quatre ans. Il faut encore attendre pour être certain. »
Le médecin bordelais reste cependant « séduit » par l'évolution de ce cas. « Cela donne tout de même une forme d'espoir, notamment en imaginant des progrès dans la thérapie génique ou la biotechnologie. Il sera peut-être possible de reproduire à plus grande échelle ce gène muté qui empêche le virus du sida de prospérer. » La communauté scientifique fait d'ailleurs preuve pour l'instant d'une certaine prudence. Même si ce résultat a été salué, tout le monde est conscient que le virus peut être encore présent en très petites quantités. Le VIH peut enfin muter et trouver une autre voie d'entrée dans le système immunitaire, par exemple en utilisant d'autres récepteurs appelés CXCR4.
Pour que l'espoir de guérison à grande échelle se concrétise, il faudra donc encore faire preuve de patience et de réalisme.
Rencontre avec le Pr Luc Montagnier le 2 mars 2012 à l'UNESCO à Paris.
Le Pr Luc Montagnier, biologiste virologue, prix Nobel de médecine 2008, a cofondé en 1993 avec l'UNESCO une fondation pour développer les recherches sur le sida.
Aujourd'hui, il explore par de nouvelles technologies, l'origine infectieuse des maladies chroniques.
Molecular Psychiatry (2012) 17, 486–493; doi:10.1038/mp.2011.179; published online 31 January 2012
M Hornig1,2, T Briese1,2, J Licinio3, R F Khabbaz4, L L Altshuler5, S G Potkin6, M Schwemmle7, U Siemetzki1, J Mintz5, K Honkavuori1, H C Kraemer8, M F Egan9, P C Whybrow5, W E Bunney6 and W I Lipkin1,2
Correspondence: Dr M Hornig, Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W. 168th St., 17th Floor, New York, NY 10032, USA. E-mail:email@example.com; Dr WI Lipkin, Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W. 168th St., 17th Floor, New York, NY 10032, USA. E-mail:firstname.lastname@example.org
Received 30 August 2011; Revised 8 November 2011; Accepted 21 November 2011
Advance online publication 31 January 2012
In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990, more than 80 studies have reported an association between BDV and a wide range of human illnesses that include MDD, bipolar disorder (BD), schizophrenia (SZ), anxiety disorder, chronic fatigue syndrome, multiple sclerosis, amyotrophic lateral sclerosis, dementia and glioblastoma multiforme. However, to date there has been no blinded case–control study of the epidemiology of BDV infection. Here, in a United States-based, multi-center, yoked case–control study with standardized methods for clinical assessment and blinded serological and molecular analysis, we report the absence of association of psychiatric illness with antibodies to BDV or with BDV nucleic acids in serially collected serum and white blood cell samples from 396 subjects, a study population comprised of 198 matched pairs of patients and healthy controls (52 SZ/control pairs, 66 BD/control pairs and 80 MDD/control pairs). Our results argue strongly against a role for BDV in the pathogenesis of these psychiatric disorders.
Borna disease virus; infection; schizophrenia; affective disorders; pathogenesis
The Silent Time Bomb Now Affecting 1 in 54 Boys in the US
By Dr. Mercola
The Centers for Disease Control (CDC) has announced that 1 in 88 children in the U.S. are now diagnosed with an autism spectrum disorder (ASD)i .
The number represents a 23 percent increase in the last two years and 78 percent in the past five years.
But that was just the average—the numbers were much greater for Hispanics (110 percent) and black children (91 percent).
The study, published in the CDC's Morbidity and Mortality Weekly Reportii , also found that ASDs are nearly five times more common among boys than girls.
Broken down, the numbers equate to 1 in 54 boys with ASDs, and 1 in 252 girls. The updated estimates are based on data collected in 14 American communities during 2008.
These communities comprised over eight percent of all American 8-year-olds that year. Interestingly, the number of children with ASDs varied widely from site to site.
The highest prevalence was found in Utah, where a staggering 1 in 47 eight-year-olds were identified with some form of ASD.
New Jersey was also far higher than the average, with 1 in 49iii . What's really going on here?
WHAT is Causing the Skyrocketing Increase in Autism Spectrum Disorders?
Personally, I don't see how anyone can look at a 78 percent increase of any health problem in a mere five years without snapping to attention. Prior to the CDC's announcement, the Canary Party, a citizens' action group on autism, rightfully predicted that the CDC would downplay the seriousness of these latest statistics.
On its new autism webpage, the CDC state they suspect some of the increase "is due to greater awareness and better identification" among some of the children.
But even taking that possibility into consideration, the statistics are truly shocking. How can one in 88 American children have some form of autistic disorder? In a normal, healthy environment, that just shouldn't happen. And the fact that it IS happening demands our immediate attention. Something is going very wrong, very fast...
While many are focusing their efforts on nailing down one culprit or another—vaccines being the perfect example—I believe taking such a narrow-minded approach can be extremely counterproductive. In my view, what we're seeing here is the culmination of what amounts to a perfect storm...
Research is now clearly showing that environmental factors play a primary role in the epidemic of autism spectrum disorders. But which environmental factors are to blame?
While vaccines have borne the brunt of people's suspicions, there's plenty of evidence suggesting there are multiple factors at play. The factor that prevents us from writing vaccines off as being harmless is the fact that toxic overload appears to be at the core of the problem, and many vaccines do indeed contribute to a child's overall toxic load. So while it's probably unreasonable to blame vaccines alone for the rapid rise in autism, it would be just as unreasonable to ignore their impact, and continue on with the one-fits-all vaccination policy as if everything is a-okay.
The majority of autism cases do appear to result from the activation or "expression," of a number of different genes, along with multiple epigenetic and environmental factors that interact to produce the traits of autism. But science is increasingly showing us just how malleable our genes are—they continuously respond to their environment, meaning, your body and everything you put into and onto it... Furthermore, there's no shortage of evidence that toxins of different sorts can wreak havoc with brain function. Add to this the more recent findings that your gut is profoundly influential for brain health, and a picture of toxic overload combined with inadequate nutrition comes into clear view.
Why We Must Insist on Invoking the Precautionary Principle
If multiple toxic exposures and poor nutrition is to blame, then trying to tease out "the" primary culprit will get us nowhere. I believe we must tackle the issue of ASD with a much wider aim, and that is to reduce ALL toxic exposure and improve nutrition. This tactic includes but is not limited to reducing the vaccine load, especially in the US where children receive the most vaccines of any country on the planet. I believe it's imperative to invoke the precautionary principle with respects to vaccines, and, at the very least, allow people to opt out if they so choose.
While vaccine advocates tend to stress the importance of so-called "herd immunity," saying the vaccine will not work unless the majority is vaccinated, there's a great price to pay by forcing everyone into a one-size-fits-all mold.
Not only are some children at greater risk for vaccine damage than others (which I'll review in a moment), but we also eliminate the ability to evaluate the health risks of vaccinations if no one is allowed to opt out. We NEED to conduct comparison studies to evaluate the health outcomes of vaccinated versus unvaccinated children, yet such studies are not done. An oft-cited reason for that is that it would be unethical to not vaccinate certain children... But this is not really a reasonable excuse today, as many parents want to opt out of one or more vaccines for their children.
Environmental Factors that May Play a Role in Autism
When looking into the possible environmental factors for autism, they are incredibly diverse. The following is just a short list of examples:
Neurologist Dr. Natasha Campbell-McBride recently shared a common thread that may be linking these and other environmental factors together, namely brain toxicity stemming from gut toxicity, otherwise known as Gut and Psychology Syndrome (GAPS). She cured her own son of autism using an all-natural treatment involving dietary changes and detoxification, and her hypothesis is in my view one of the most elegant.
GAPS: An Elegant Explanation of the Roots of Autism
Dr. Campbell-McBride is convinced that autistic children are born with perfectly normal brains and sensory organs, but that abnormal gut flora, passed on from their mother and father, leads to devastating gut and brain toxicity. In children with Gut and Psychology Syndrome (GAPS), toxicity flowing from their gut throughout their bodies and into their brains, literally clogs the brain with toxicity, preventing it from performing its normal function and processing sensory information.
Total Video Length: 1:13:21
But what leads to such devastatingly abnormal gut flora?
Dr. Campbell discovered that a large percentage of mothers of autistic children were bottle-fed. Then, as they received many courses of antibiotics throughout their childhood, they developed increasingly worse abnormalities in their gut flora, which in turn was passed on to their children. Add to that a diet of processed foods and the use of birth control pills, and the damage to a woman's gut flora deepens even further, and each generation quickly gets worse and worse, unless active remediation is undertaken. According to Dr. Campbell-McBride:
"Many of these modern factors created a whole plethora of young ladies in our modern world who have got quite deeply abnormal gut flora by the time they are ready to have their first child."
Vaccination Policy is Oftentimes the "Straw that Breaks the Camel's Back"
Dr. Campbell-McBride's book Gut and Psychology Syndrome contains an entire chapter outlining what health care professionals need to do to improve the vaccination strategy, because the standard vaccination protocol is bound to damage GAPS babies.
"It's a matter of the last straw breaking the camel's back. If the child is damaged enough, the vaccine can provide that last straw. But if it doesn't provide that last straw in a particular child, then it will get the child closer to the breaking point."
Fortunately, it's possible to rather inexpensively identify GAPS within the first weeks of your baby's life, which can help you make better-informed decisions about vaccinations, and about how to proceed to set your child on the path to a healthy life. The entire process for identifying children who would be at risk for developing autism from a vaccine is described in her book, but to sum it up, in her practice she starts out by collecting a complete health history of the parents, and their gut health is assessed. Then, within the first few days of life, the stool of the child can be analyzed to determine the state of her gut flora, followed by a urine test to check for metabolites, which can give you a picture of the state of your child's immune system.
These tests are available in most laboratories around the world and cost a very reasonable amount, about $80-100 per test -- peanuts compared to the incredible expense of treating an autistic child once the damage is done.
In my view it is absolutely VITAL to perform this analysis BEFORE you consider vaccinating your child. If the test results are normal the likelihood of autism after vaccines is dramatically reduced. As Dr. Campbell-McBride states, she has yet to find an autistic child with normal bowel flora. If you find that your baby has abnormal gut microflora, or begins to develop symptoms of autism a year or two later, the GAPS program should be started immediately, as the younger the child is when you start the treatment, the better the results. The child should not be given any vaccines until their microflora tests normal. For more information about the GAPS Nutritional Program, including the two types of GAPS diets, and the importance of fermented foods, please review this previous article.
Thoughts on Reversing the Trajectory of Autism Spectrum Disorders
Autism is a complex condition with many contributing factors and it takes a multi-faceted approach to treat it. We're now also beginning to understand it requires a multi-faceted approach to prevent it. Hopefully, more people will begin to take Dr. Campbell-McBride's information to heart and put it to practice so that more children may be spared from the get-go. But even that's not going far enough. We must tackle this problem from all angles, and that also includes:
Posted By Dr. Mercola | April 17 2012