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25 juin 2012 1 25 /06 /juin /2012 10:44
Molecular Psychiatry (2012) 17, 719–727; doi:10.1038/mp.2011.53; published online 17 May 2011 Telomere length and early severe social deprivation: linking early adversity and cellular aging S S Drury1,6, K Theall2,6, M M Gleason1, A T Smyke1, I De Vivo3, J Y Y Wong3, N A Fox4, C H Zeanah1 and C A Nelson5 1Department of Psychiatry, Tulane University, New Orleans, LA, USA 2Department of Community Health Sciences, Tulane University, New Orleans, LA, USA 3Harvard School of Public Health, Harvard University, Boston, MA, USA 4Department of Human Development, University of Maryland, College Park, MD, USA 5Department of Pediatrics and Neuroscience, Harvard University, Boston, MA, USA Correspondence: Dr SS Drury, Department of Psychiatry and Behavioral Health, 1440 Tulane Ave, TB 52, New Orleans, LA 70112, USA. E-mail: sdrury@tulane.edu 6These authors contributed equally to this work. Received 19 January 2011; Revised 22 March 2011; Accepted 28 March 2011 Advance online publication 17 May 2011 Top of page Abstract Accelerated telomere length attrition has been associated with psychological stress and early adversity in adults; however, no studies have examined whether telomere length in childhood is associated with early experiences. The Bucharest Early Intervention Project is a unique randomized controlled trial of foster care placement compared with continued care in institutions. As a result of the study design, participants were exposed to a quantified range of time in institutional care, and represented an ideal population in which to examine the association between a specific early adversity, institutional care and telomere length. We examined the association between average relative telomere length, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institutional care quantified as the percent of time at baseline (mean age 22 months) and at 54 months of age that each child lived in the institution. A significant negative correlation between T/S ratio and percentage of time was observed. Children with greater exposure to institutional care had significantly shorter relative telomere length in middle childhood. Gender modified this main effect. The percentage of time in institutional care at baseline significantly predicted telomere length in females, whereas the percentage of institutional care at 54 months was strongly predictive of telomere length in males. This is the first study to demonstrate an association between telomere length and institutionalization, the first study to find an association between adversity and telomere length in children, and contributes to the growing literature linking telomere length and early adversity.

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