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7 novembre 2012 3 07 /11 /novembre /2012 08:09
Nature Reviews Drug Discovery 11, 860–872 (1 November 2012) Eva van Rooij Eric N. Olson MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles Eva van Rooij & Eric N. Olson Abstract In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.

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