Plant Physiol Biochem. 2011 Feb;49(2):131-7. Epub 2010 Nov 18.
Novel antifungal defensins from Nigella sativa L. seeds.
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str. 16/10, 117997 Moscow, Russian Federation. firstname.lastname@example.org
From seeds of Nigella sativa L. (Ranunculaceae), an endemic plant of Uzbekistan, two novel defensins named Ns-D1 and Ns-D2, were isolated and sequenced.
The peptides differ by a single amino acid residue and show high sequence similarity to Raphanus sativus L. defensins Rs-AFP1 and Rs-AFP2.
The Ns-D1 and Ns-D2 defensins display strong although divergent antifungal activity towards a number of phytopathogenic fungi.
High antifungal activity of N. sativa defensins makes them promising candidates for engineering pathogen-resistant plants.
PMID: 21144761 [PubMed - in process]