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18 avril 2011 1 18 /04 /avril /2011 11:45

Plant Physiol Biochem. 2011 Feb;49(2):131-7. Epub 2010 Nov 18.

Novel antifungal defensins from Nigella sativa L. seeds.

Rogozhin EAOshchepkova YIOdintsova TIKhadeeva NVVeshkurova ONEgorov TAGrishin EVSalikhov SI.

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str. 16/10, 117997 Moscow, Russian Federation. rea21@list.ru

From seeds of Nigella sativa L. (Ranunculaceae), an endemic plant of Uzbekistan, two novel defensins named Ns-D1 and Ns-D2, were isolated and sequenced.

The peptides differ by a single amino acid residue and show high sequence similarity to Raphanus sativus L. defensins Rs-AFP1 and Rs-AFP2.

The Ns-D1 and Ns-D2 defensins display strong although divergent antifungal activity towards a number of phytopathogenic fungi.


High antifungal activity of N. sativa defensins makes them promising candidates for engineering pathogen-resistant plants.

PMID: 21144761 [PubMed - in process]

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