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25 septembre 2011 7 25 /09 /septembre /2011 11:20
Nature Reviews Cancer 11, 690 (October 2011) | doi:10.1038/nrc3141

Cell migration: Cytokine cues

Sarah Seton-Rogers

Abstract

The generation of contractile forces in both tumour cells and the surrounding stromal cells is necessary to create a permissive environment for cancer cell migration and metastasis, but the signals controlling actomyosin contractility are not well understood. Chris Marshall's laboratory working on melanoma cell migration and Cedric Gaggioli's laboratory working on carcinoma-associated fibroblasts (CAFs) in squamous cell carcinoma have shown that a cytokine signalling pathway activating the kinase JAK1 is important in both cell types.

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