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12 février 2012 7 12 /02 /février /2012 20:48
Microbiology of regressive autism.

AuthorsFinegold SM, et al. Show all Journal
Anaerobe. 2011 Dec 22. [Epub ahead of print]

Affiliation
Infectious Diseases Section (111 F), VA Medical Center WLA, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, CA, USA; Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA.

Abstract
This manuscript summarizes some of our earlier work on the microbiology of autism subjects' stool specimens, as compared with stools from control subjects. Our most recent data indicating that Desulfovibrio may play an important role in regressive autism is also presented. In addition, we present information on antimicrobial susceptibility patterns of Desulfovibrio using the CLSI agar dilution susceptibility technique. In addition, we summarize data from our earlier studies showing the impact of various antimicrobial agents on the indigenous bowel flora. This shows that penicillins and cephalosporins, as well as clindamycin, have a major impact on the normal bowel flora and therefore might well predispose subjects to overgrowth of such organisms as Clostridium difficile, and of particular importance for autism, to Desulfovibrio.

Published by Elsevier Ltd.
PMID 22202440 [PubMed - as supplied by publisher]

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