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21 août 2012 2 21 /08 /août /2012 16:25
Immunol Lett. 2008 Dec 22;121(2):105-9. Epub 2008 Oct 18.
Bioplex analysis of plasma cytokines in Alzheimer's disease and mild cognitive impairment.
Lee KS, Chung JH, Lee KH, Shin MJ, Oh BH, Hong CH.

Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Erratum in
Immunol Lett. 2009 Mar 24;123(1):96.


Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. 
Sixty-nine subjects were consecutively recruited from October 2005 to February 2007.
 Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. 
To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. 
The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group 

PMID: 18930766 

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