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19 avril 2011 2 19 /04 /avril /2011 17:17

Lutter contre les cystites grâce à la canneberge

E-santé, avril 2011, www.e-sante.fr

Les études portant sur l'efficacité de la canneberge contre les infections urinaires montrent que le mécanisme d'action de ce fruit est tout simplement mécanique.


Le « vaccinium macrocarpon » contient des antioxydants particuliers, appelés proanthocyanidines (PAC), qui viennent se coller aux bactéries responsables de la plupart des cystites, les escherichia coli, et les empêchent de déclencher l'infection.


On manque encore de preuves scientifiques formelles sur l'efficacité des canneberges. Pourtant les médecins n'hésitent pas à recommander leur absorption pour des questions de tolérance, afin d'éviter le recours systématique aux antibiotiques.


Toutefois il faut savoir que les compléments alimentaires à base de canneberge ne sont pas tous efficaces face aux escherichia coli.


Certains d'entre eux ne comportent pas assez de proanthocyanidines pour prévenir les infections urinaires. Pour rappel, les autorités sanitaires françaises recommandent une dose de 36 mg de proanthocyanidines par jour, soit l'équivalent d'un verre de 300 ml de jus de canneberge.



J Biol Regul Homeost Agents. 2011 Jan-Mar;25(1):27-35.

Effect of phytochemical concentrations on biological activities of cranberry extracts.

Menghini L, Leporini L, Scanu N, Pintore G, La Rovere R, Di Filippo ES, Pietrangelo T, Fulle S.

Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara, Chieti, Italy. lmenghini@unich.it


Plants of cranberry (Vaccinium macrocarpon) furnish edible fruits and derivates that have been used for the prevention and treatment of urinary tract infections.

In the present work we compare two commercial extracts that contain proanthocyanins (PACs) at 4 percent and 20 percent for antimicrobial, antiproliferative, antiradical and protective properties against oxidative stress on cell lines. Both extracts showed antimicrobial activity (MIC values range 3-100 microg/ml). Extract at 20 percent PACs showed higher antiproliferative activity against HepG2 and MCF7 cells, but not against C2C12 cells.

Both extracts showed a dose-dependent free-radical scavenging capacity, and a protective effect on the cell damage was also revealed by reduction of intracellular active oxygen species release.

Cranberry extracts confirmed antioxidative properties and efficacy in reduction of cell viability that resulted stronger against tumor cells.

The pretreatment with cranberry extracts, furthermore, reveal an increase of cell resistance against oxidative stress, suggesting a potential role as a dietary supplement in preventing free-radical damage.

The proanthocyanidin content is critical to determine the extract efficacy.

In cellular experiments the extracts resulted clearly differentiated in their activity, and the activity was strongly influenced by PACs content.

Only in DPPH test the free radical scavenging activity seemed to be directly related to proanthocyanidins content.


PMID: 21382271 [PubMed - in process]


J Obstet Gynaecol Can. 2010 Nov;32(11):1082-101.

Recurrent urinary tract infection.

[Article in English, French]

Epp ALarochelle ALovatsis DWalter JEEaston WFarrell SAGirouard LGupta CHarvey MARobert MRoss SSchachter JSchulz JAWilkie DEhman WDomb SGagnon AHughes OKonkin J,Lynch JMarshall CSociety of Obstetricians and Gynaecologists of Canada.

OBJECTIVE: to provide an update of the definition, epidemiology, clinical presentation, investigation, treatment, and prevention of recurrent urinary tract infections in women.


OPTIONS: continuous antibiotic prophylaxis, post-coital antibiotic prophylaxis, and acute self-treatment are all efficient alternatives to prevent recurrent urinary tract infection. Vaginal estrogen and cranberry juice can also be effective prophylaxis alternatives.


EVIDENCE: a search of PubMed and The Cochrane Library for articles published in English identified the most relevant literature. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. There were no date restrictions.


VALUES: this update is the consensus of the Sub-Committee on Urogynaecology of the Society of Obstetricians and Gynaecologists of Canada. Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care (Table 1).


OPTIONS: recurrent urinary tract infections need careful investigation and can be efficiently treated and prevented. Different prophylaxis options can be selected according to each patient's characteristics.

PMID: 21176321 [PubMed - indexed for MEDLINE]





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duval5tatiana 15/06/2011 15:22

Moi j'ai trouvé une astuce. Je prends Urell géléules. Impeccable.