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23 décembre 2011 5 23 /12 /décembre /2011 18:36
Metastasis: Signalling in transit

Sarah Seton-Rogers

Abstract

The microenvironment of a primary tumour has been recognized as an important player in cancer progression, but whether circulating tumour cells respond to additional metastatic signals during their transit through the vasculature is unclear.

Given the high concentrations of growth factors and cytokines that are contained in platelets, Labelle, Begum and Hynes proposed that, in addition to their known roles in promoting cell adhesion and protecting tumour cells from death, platelets might provide pro-metastatic signals to circulating tumour cells.


Nature Reviews Cancer 12, 4-5 (January 2012)

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