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23 avril 2011 6 23 /04 /avril /2011 08:43
Toxicol Ind Health. 2010 Nov;26(10):667-70. Epub 2010 Jul 14.

Caffeine as a photoprotective agent for diminishing phototoxicity.


Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Foundation, Avenida Wai Long, Taipa, Macau SAR, PR China. savio.yim.tong.szeto@inet.polyu.edu.hk

Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity.

Result showed that caffeine at 5 µmol/L was able to reduce 5-methoxypsoralen-induced phototoxicity with ultraviolet C (UVC) exposure.

[PubMed - indexed for MEDLINE]

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