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5 décembre 2011 1 05 /12 /décembre /2011 23:32
Acta Pharmacologica Sinica 32, 1431-1432 (December 2011) | doi:10.1038/aps.2011.154

Cell adhesion, inflammation and therapy: Old ideas and a significant step forward

Roberto González-amaro

Abstract
Cell-to-cell adhesion as well as the interaction of cells with the extracellular matrix are key phenomena in different physiological and pathological conditions, including embryogenesis, blood coagulation, lymphocyte homing, immune response, angiogenesis, metastasis, thrombosis and inflammation1, 2. Thus, it has been widely proposed that cell adhesion molecules are an important therapeutic target in a wide array of diseases with high impact on public health, including atherosclerosis, thromboembolic disorders, cancer, graft rejection and autoimmune inflammatory conditions1, 2.

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