Chronobiology and depression: the seasonal depressions. Clinical aspects, physiopathology and specific treatments.
Service de Psychologie Médicale, CHRU, Hôpital Jeanne-d' Arc, Toul.
Seasonal Affective Disorder, described in 1984 by Rosenthal in the United States of America, was individualized in France since this concept entered the DSM III-R in 1989.
Firstly, the purpose of the authors was an attempt to draw the historical evolution of the concept, his clinical and epidemiological aspects.
Secondly, they considered the physiological hypothesises, which followed two ways of research: on the one hand the impairment of endogenous chronobiological rhythms, especially melatonin and serotonin rhythms; on the other hand the photoperiodical hypothesis.
Thildly, the authors proposed the main specific prospects of treatments: chimiotherapeutic methods--particularly 5-methoxypsoralen--and non chimiotherapeutic such as phototherapy.
- [PubMed - indexed for MEDLINE]