Pak J Pharm Sci. 2011 Apr;24(2):227-31.
Report: Treatment of Nigella sativa in experimental sepsis model in rats.
Department of Infectious Diseases and Clinical Bacteriology, Medical Park Hospital, Istanbul,Turkey.
This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model.
Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3).
Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups.
Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p<0.03, and p<0.02, respectively).
Additionally, SOD levels in group 3 were found to be higher than group 2 (p<0.02).
Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models.
PMID: 21454175 [PubMed - in process]