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Control of pathogens and pathobionts by the gut microbiota Nobuhiko Kamada, Grace Y Chen, Naohiro Inohara & Gabriel Núñez AffiliationsCorresponding author Nature Immunology 14, 685–690 (2013) doi:10.1038/ni.2608 Received 27 February 2013 Accepted 09 April 2013 Published online 18 June 2013 A dense resident microbial community in the gut, referred as the commensal microbiota, coevolved with the host and is essential for many host physiological processes that include enhancement of the intestinal epithelial barrier, development of the immune system and acquisition of nutrients. A major function of the microbiota is protection against colonization by pathogens and overgrowth of indigenous pathobionts that can result from the disruption of the healthy microbial community. The mechanisms that regulate the ability of the microbiota to restrain pathogen growth are complex and include competitive metabolic interactions, localization to intestinal niches and induction of host immune responses. Pathogens, in turn, have evolved strategies to escape from commensal-mediated resistance to colonization. Thus, the interplay between commensals and pathogens or indigenous pathobionts is critical for controlling infection and disease. Understanding pathogen-commensal interactions may lead to new therapeutic approaches to treating infectious diseases. Hooper, L.V. & Macpherson, A.J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 10, 159–169 (2010). CASISIPubMedArticle Dridi, B., Raoult, D. & Drancourt, M. Archaea as emerging organisms in complex human microbiomes. Anaerobe 17, 56–63 (2011). PubMedArticle Pridmore, R.D. et al. The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proc. Natl. Acad. Sci. USA 101, 2512–2517 (2004). CASADSPubMedArticle Turnbaugh, P.J., Backhed, F., Fulton, L. & Gordon, J.I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213–223 (2008). CASISIPubMedArticle Matamoros, S., Gras-Leguen, C., Le Vacon, F., Potel, G. & de La Cochetiere, M.F. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 21, 167–173 (2013). CASPubMedArticle Hasegawa, M. et al. Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect. Immun. 78, 639–650 (2010). CASPubMedArticle Koropatkin, N.M., Cameron, E.A. & Martens, E.C. How glycan metabolism shapes the human gut microbiota. Nat. Rev. Microbiol. 10, 323–335 (2012). CASPubMed Willing, B. et al. Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm. Bowel Dis. 15, 653–660 (2009). ISIPubMedArticle Li, E. et al. Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoS ONE 7, e26284 (2012). CASADSPubMedArticle Oh, P.L. et al. Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am. J. Transplant. 12, 753–762 (2012). CASPubMedArticle Hammami, R., Fernandez, B., Lacroix, C. & Fliss, I. Anti-infective properties of bacteriocins: an update. Cell Mol. Life Sci. advance online publication, doi:doi:10.1007/s00018-012-1202-3 (30 October 2012). Article Schamberger, G.P. & Diez-Gonzalez, F. Selection of recently isolated colicinogenic Escherichia coli strains inhibitory to Escherichia coli O157:H7. J. Food Prot. 65, 1381–1387 (2002). ISIPubMed Turovskiy, Y., Sutyak Noll, K. & Chikindas, M.L. The aetiology of bacterial vaginosis. J. Appl. Microbiol. 110, 1105–1128 (2011). CASPubMedArticle Cherrington, C.A., Hinton, M., Pearson, G.R. & Chopra, I. Short-chain organic acids at ph 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation. J. Appl. Bacteriol. 70, 161–165 (1991). CASPubMedArticle Shin, R., Suzuki, M. & Morishita, Y. Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7. J. Med. Microbiol. 51, 201–206 (2002). CASPubMed Fukuda, S. et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469, 543–547 (2011). CASADSISIPubMedArticle Ceuppens, S. et al. Enterotoxin production by Bacillus cereus under gastrointestinal conditions and their immunological detection by commercially available kits. Foodborne Pathog. Dis. 9, 1130–1136 (2012). CASPubMedArticle Momose, Y., Hirayama, K. & Itoh, K. Competition for proline between indigenous Escherichia coli and E. coli O157:H7 in gnotobiotic mice associated with infant intestinal microbiota and its contribution to the colonization resistance against E. coli O157:H7. Antonie Van Leeuwenhoek 94, 165–171 (2008). CASPubMedArticle Momose, Y., Hirayama, K. & Itoh, K. Effect of organic acids on inhibition of Escherichia coli O157:H7 colonization in gnotobiotic mice associated with infant intestinal microbiota. Antonie Van Leeuwenhoek 93, 141–149 (2008). CASPubMedArticle Fabich, A.J. et al. Comparison of carbon nutrition for pathogenic and commensal Escherichia coli strains in the mouse intestine. Infect. Immun. 76, 1143–1152 (2008). CASISIPubMedArticle Leatham, M.P. et al. Precolonized human commensal Escherichia coli strains serve as a barrier to E. coli O157:H7 growth in the streptomycin-treated mouse intestine. Infect. Immun. 77, 2876–2886 (2009). CASPubMedArticle Gantois, I. et al. Butyrate specifically down-regulates Salmonella pathogenicity island 1 gene expression. Appl. Environ. Microbiol. 72, 946–949 (2006). CASPubMedArticle Pacheco, A.R. et al. Fucose sensing regulates bacterial intestinal colonization. Nature 492, 113–117 (2012). CASADSPubMedArticle Marteyn, B. et al. Modulation of Shigella virulence in response to available oxygen in vivo. Nature 465, 355–358 (2010). CASADSISIPubMedArticle Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731–734 (2005). CASADSISIPubMedArticle Vaishnava, S., Behrendt, C.L., Ismail, A.S., Eckmann, L. & Hooper, L.V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858–20863 (2008). PubMedArticle Vaishnava, S. et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255–258 (2011). CASADSPubMedArticle Satoh-Takayama, N. et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29, 958–970 (2008). CASISIPubMedArticle Sanos, S.L. et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat. Immunol. 10, 83–91 (2009). CASISIPubMedArticle Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282–289 (2008). CASISIPubMedArticle Kiss, E.A. et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334, 1561–1565 (2011). CASADSISIPubMedArticle Qiu, J. et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 36, 92–104 (2012). CASPubMedArticle Frantz, A.L. et al. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol. 5, 501–512 (2012). CASPubMedArticle Fagarasan, S., Kawamoto, S., Kanagawa, O. & Suzuki, K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 28, 243–273 (2010). CASISIPubMedArticle Suzuki, K. et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 33, 71–83 (2010). CASPubMedArticle Strugnell, R.A. & Wijburg, O.L. The role of secretory antibodies in infection immunity. Nat. Rev. Microbiol. 8, 656–667 (2010). CASPubMedArticle Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl. Acad. Sci. USA 106, 15813–15818 (2009). ADSPubMedArticle Salzman, N.H. et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11, 76–83 (2010). CASISIPubMedArticle Macpherson, A.J., Geuking, M.B. & McCoy, K.D. Homeland security: IgA immunity at the frontiers of the body. Trends Immunol. 33, 160–167 (2012). CASPubMedArticle Franchi, L. et al. NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13, 449–456 (2012). CASPubMedArticle Ivanov, I.I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485–498 (2009). CASISIPubMedArticle Bohnhoff, M., Drake, B.L. & Miller, C.P. Effect of streptomycin on susceptibility of intestinal tract to experimental Salmonella infection. Proc. Soc. Exp. Biol. Med. 86, 132–137 (1954). CASPubMed Endt, K. et al. The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog. 6, e1001097 (2010). CASPubMedArticle Ayres, J.S., Trinidad, N.J. & Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat. Med. 18, 799–806 (2012). CASPubMedArticle Rupnik, M., Wilcox, M.H. & Gerding, D.N. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat. Rev. Microbiol. 7, 526–536 (2009). CASISIPubMedArticle Ng, J. et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 139, 542–552 (2010). CASISIPubMedArticle Hasegawa, M. et al. Protective role of commensals against Clostridium difficile infection via an IL-1beta-mediated positive-feedback loop. J. Immunol. 189, 3085–3091 (2012). CASPubMedArticle Arias, C.A. & Murray, B.E. The rise of the Enterococcus: beyond vancomycin resistance. Nat. Rev. Microbiol. 10, 266–278 (2012). CASPubMedArticle Brandl, K. et al. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature 455, 804–807 (2008). CASADSISIPubMedArticle Kinnebrew, M.A. et al. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J. Infect. Dis. 201, 534–543 (2010). CASPubMedArticle Ubeda, C. et al. Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infect. Immun. 81, 965–973 (2013). CASPubMedArticle Giel, J.L., Sorg, J.A., Sonenshein, A.L. & Zhu, J. Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS ONE 5, e8740 (2010). CASADSPubMedArticle Kane, M. et al. Successful transmission of a retrovirus depends on the commensal microbiota. Science 334, 245–249 (2011). Kuss, S.K. et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 334, 249–252 (2011). CASADSPubMedArticle Le Bouguenec, C. & Schouler, C. Sugar metabolism, an additional virulence factor in enterobacteria. Int. J. Med. Microbiol. 301, 1–6 (2011). CASPubMedArticle Perna, N.T. et al. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 409, 529–533 (2001). CASADSISIPubMedArticle Bertin, Y. et al. Enterohaemorrhagic Escherichia coli gains a competitive advantage by using ethanolamine as a nitrogen source in the bovine intestinal content. Environ. Microbiol. 13, 365–377 (2011). CASPubMedArticle Kamada, N. et al. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336, 1325–1329 (2012). CASADSPubMedArticle Crosa, J.H. & Walsh, C.T. Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiol. Mol. Biol. Rev. 66, 223–249 (2002). CASISIPubMedArticle Fischbach, M.A., Lin, H., Liu, D.R. & Walsh, C.T. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat. Chem. Biol. 2, 132–138 (2006). CASPubMedArticle Lupp, C. et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2, 204 (2007). CASISIPubMedArticle Furne, J., Springfield, J., Koenig, T., DeMaster, E. & Levitt, M.D. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem. Pharmacol. 62, 255–259 (2001). CASISIPubMedArticle Levitt, M.D., Furne, J., Springfield, J., Suarez, F. & DeMaster, E. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J. Clin. Invest. 104, 1107–1114 (1999). CASPubMedArticle Winter, S.E. et al. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature 467, 426–429 (2010). CASADSISIPubMedArticle Thiennimitr, P. et al. Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota. Proc. Natl. Acad. Sci. USA 108, 17480–17485 (2011). ADSPubMedArticle Kolios, G., Valatas, V. & Ward, S.G. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology 113, 427–437 (2004). CASISIPubMedArticle Reinders, C.A. et al. Rectal nitric oxide and fecal calprotectin in inflammatory bowel disease. Scand. J. Gastroenterol. 42, 1151–1157 (2007). CASPubMedArticle Winter, S.E. et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339, 708–711 (2013). CASADSPubMedArticle Wu, L. et al. Recognition of host immune activation by Pseudomonas aeruginosa. Science 309, 774–777 (2005). CASADSISIPubMedArticle Kaper, J.B., Nataro, J.P. & Mobley, H.L. Pathogenic Escherichia coli. Nat. Rev. Microbiol. 2, 123–140 (2004). CASPubMedArticle Reeves, A.E., Koenigsknecht, M.J., Bergin, I.L. & Young, V.B. Suppression of Clostridium difficile in the gastrointestinal tracts of germfree mice inoculated with a murine isolate from the family Lachnospiraceae. Infect. Immun. 80, 3786–3794 (2012). CASPubMedArticle van Nood, E. et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407–415 (2013). CASPubMedArticle Petrof, E.O. et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome 1, 3 (2013). Article Ubeda, C. et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 209, 1445–1456 (2012).

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