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10 juillet 2013 3 10 /07 /juillet /2013 06:44
Yasmine Belkaid & Shruti Naik AffiliationsCorresponding author Nature Immunology 14, 646–653 (2013) doi:10.1038/ni.2604 Received 05 February 2013 Accepted 02 April 2013 Published online 18 June 2013 The body is composed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of which are in close apposition with distinct commensal niches. Mammals have formed an evolutionary partnership with the microbiota that is critical for metabolism, tissue development and host defense. Despite our growing understanding of the impact of this host-microbe alliance on immunity in the gastrointestinal tract, the extent to which individual microenvironments are controlled by resident microbiota remains unclear. 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