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7 novembre 2012 3 07 /11 /novembre /2012 08:16
Nature Reviews Drug Discovery 11, 832 (November 2012) | doi:10.1038/nrd3882 Bone disorders: Clopidogrel prevents bone loss Charlotte Harrison Abstract This study investigated the role of P2Y purinergic receptor 12 (P2Y12) in osteoclast function. ADP-mediated stimulation of P2Y12 on osteoclasts enhanced adhesion and resorptive activity; these effects were not seen in P2y12−/− osteoclasts.

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