Overblog Suivre ce blog
Editer l'article Administration Créer mon blog
23 avril 2011 6 23 /04 /avril /2011 08:21
J Nat Med. 2011 Apr;65(2):370-4. Epub 2010 Nov 17.

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.


College of Pharmacy, Chungbuk National University, 410 Seongbong-ro, Heungduk-gu, Cheongju 361-763, Korea.


The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines.

Activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins:

osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10).

Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner.

In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells.


[PubMed - in process]

Partager cet article

Repost 0
Published by Chronimed - dans Nutrition
commenter cet article