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23 avril 2011 6 23 /04 /avril /2011 08:45
FEBS Lett. 2010 Jun 3;584(11):2321-6. Epub 2010 Apr 4.

Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation.


Department of Cellular Biology, University of Calabria, Cosenza, Italy. mamissina@yahoo.it

In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations.

B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation.

Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content.

An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication.

These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.


[PubMed - indexed for MEDLINE]

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