Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation.
Department of Cellular Biology, University of Calabria, Cosenza, Italy. email@example.com
In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations.
B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation.
Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content.
An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication.
These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.
- [PubMed - indexed for MEDLINE]