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22 avril 2012 7 22 /04 /avril /2012 12:19
Nat Prod Res. 2011 Aug 11.

Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba.
Naz T, Mosaddik A, Rahman MM, Muhammad I, Haque ME, Cho SK.

a Department of Pharmacy , University of Rajshahi , Rajshahi 6205 , Bangladesh.


The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities.
Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3).
This is the first report of isolation of compounds (1) and (2) from P. chaba.
It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC(50) values of 0.76 and 0.83 µg mL(-1), respectively.
These compounds were also found to have weak antibacterial and antileishmanial activities.
This is the first report about the antileishmanial activity of Piper isolates.

PMID: 21834629

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Published by Chronimed - dans Nutrition
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