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21 avril 2012 6 21 /04 /avril /2012 18:43
Phytother Res. 2012 Apr 20. doi: 10.1002/ptr.4678. [Epub ahead of print]
Placebo-controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration - New Evidence on the Antiinflammatory Mode of Action of Bromelain.
Müller S, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P.
Source
Institute for Clinical Pharmacology, Medical Faculty, University of Rostock, Schillingallee 70, 18057, Rostock, Germany. silke.mueller@med.uni-rostock.de, p.meiser@ursapharm.de.
Abstract
Bromelain has been used for treatment of inflammatory diseases for decades. However, the exact mechanism of action remains poorly understood. While in vitro investigations have shown conflicting effects on the release of various cytokines, no in vivo data were available. In this study, the effects on inflammation-related cytokines of two doses of bromelain were tested in a single dose placebo-controlled 3 × crossover randomized clinical trial. Cytokine circadian profiles were used to investigate the effects of bromelain on the human immune system by using stimulated whole-blood leukocytes. The effects seen in these cultures demonstrated a significant shift in the circadian profiles of the Th1 cell mediator interferon gamma (IFNγ; p 

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Published by Chronimed - dans Nutrition
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