Overblog Suivre ce blog
Editer l'article Administration Créer mon blog
24 avril 2012 2 24 /04 /avril /2012 15:15
 
Molecular Psychiatry (2012) 17, 486–493; doi:10.1038/mp.2011.179; published online 31 January 2012

Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder

 
M Hornig1,2, T Briese1,2, J Licinio3, R F Khabbaz4, L L Altshuler5, S G Potkin6, M Schwemmle7, U Siemetzki1, J Mintz5, K Honkavuori1, H C Kraemer8, M F Egan9, P C Whybrow5, W E Bunney6 and W I Lipkin1,2
  1. 1Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA
  2. 2Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA
  3. 3John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
  4. 4Centers for Disease Control and Prevention, Atlanta, GA, USA
  5. 5Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
  6. 6University of California Irvine, Irvine, CA, USA
  7. 7Department of Virology, Universitätsklinikum, Freiburg, Germany
  8. 8Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
  9. 9Clinical Neuroscience, Merck & Company, North Wales, PA, USA

Correspondence: Dr M Hornig, Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W. 168th St., 17th Floor, New York, NY 10032, USA. E-mail:mady.hornig@columbia.edu; Dr WI Lipkin, Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W. 168th St., 17th Floor, New York, NY 10032, USA. E-mail:wil2001@columbia.edu

Received 30 August 2011; Revised 8 November 2011; Accepted 21 November 2011
Advance online publication 31 January 2012

Top

Abstract

In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990, more than 80 studies have reported an association between BDV and a wide range of human illnesses that include MDD, bipolar disorder (BD), schizophrenia (SZ), anxiety disorder, chronic fatigue syndrome, multiple sclerosis, amyotrophic lateral sclerosis, dementia and glioblastoma multiforme. However, to date there has been no blinded case–control study of the epidemiology of BDV infection. Here, in a United States-based, multi-center, yoked case–control study with standardized methods for clinical assessment and blinded serological and molecular analysis, we report the absence of association of psychiatric illness with antibodies to BDV or with BDV nucleic acids in serially collected serum and white blood cell samples from 396 subjects, a study population comprised of 198 matched pairs of patients and healthy controls (52 SZ/control pairs, 66 BD/control pairs and 80 MDD/control pairs). Our results argue strongly against a role for BDV in the pathogenesis of these psychiatric disorders.

Keywords: 

Borna disease virus; infection; schizophrenia; affective disorders; pathogenesis

Partager cet article

Repost 0
Published by Chronimed - dans Infections froides
commenter cet article

commentaires