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15 janvier 2012 7 15 /01 /janvier /2012 08:16
Autistic Kids Possess A Bacteria in Their Gut Different From Non-Autistic Counterparts Autistic kids harbor a form of bacteria in their guts that is not found in those without autism, a new study suggests. The study to be published in mBio journal was carried out by Columbia University research team that included Brent Williams and colleagues. The research team pointed out that the microorganism communities found in autistic kids’ guts are completely different from those found in non-autistic kids. But whether these differences have anything to do with vulnerability to autism is still unclear. The bacteria that fall under Sutterella group represented a huge population of microorganisms found in 12 of 23 samples of tissues taken from autistic kids’ guts, but these microorganisms were not found in non-autistic kids’ samples. The reason behind this is unknown. Jorge Benach from Stony Brook University who reviewed the study explains, “Suterella has been tied to gastrointestinal problems but it is still unclear whether it’s a pathogen or not.” According to Benach, the study was exclusively strong because tissue samples were taken from patients’ guts. “Stool samples were primly used in most work that linked the gut microbiome to autism,” says Benach, but the stool samples do not precisely represent actual microbes around the intestinal wall. The Benach believes that despite being statistically powerful the study is just an observation that has to be thoroughly followed to determine the role of Sutterella in causing problems in the gut. POSTED BY ADMIN ON MONDAY, JANUARY 9, 2012 AT 5:22 AM FILED UNDER MENTAL HEALTH · TAGGED Specific gut bacterium found in autistic children, shows study Scientists have found that gastrointestinal problems commonly occur in childrensuffering from autism. As an important investigation on this front, professionals from the Columbia University have put forth that high proportions of abacteriumcalled Sutterella in the gut could be the reason behind gastrointestinal troubles observed in autistic children. As part of the trial, 23 autistic children and 9 normal kids were inspected. After examining the subjects’ intestinal biopsies, the team also accessed Sutterella-specific molecular assays for precise identification of the bacterium. “These findings shine a light on a bacterium about which we know very little, in a disorder for which we have few answers. There is much work to be done toward understanding the role Sutterella plays in autism, the microbiota, infections, and inflammation,” commented Brent Williams, PhD, the lead author on the study. The outcomes showed that more than half of the children suffering from autism and gastrointestinal problems seemingly carried Sutterella in their intestinal biopsies. On the other hand, normal children with gastrointestinal problems did not seem to possess Sutterella in theirintestines. Notably, greater proportions of Sutterella were present in the intestinal tissue of autistic children. However, the team is not yet clear whether the bacterium could be considered a humanpathogen. Also, the primary reason for this association between gastrointestinal conditions and autism is not known by scientists presently. The study is published in the journal, mBio. Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances 1. Brent L. Williams, 2. Mady Hornig, 3. Tanmay Parekh, and 4. W. Ian Lipkin +Author Affiliations 1. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA 1. Address correspondence to Brent L. Williams, bw2101@columbia.edu. 1. Editor Christine Biron, Brown University

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