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AuthorsMazurek MO, et al. Show all Journal J Abnorm Child Psychol. 2012 Aug 1. [Epub ahead of print] Affiliation Department of Health Psychology and Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri - Columbia, 205 Portland Street, Columbia, MO, 65211, USA, firstname.lastname@example.org. Abstract Children with autism spectrum disorders (ASD) experience high rates of anxiety, sensory processing problems, and gastrointestinal (GI) problems; however, the associations among these symptoms in children with ASD have not been previously examined. The current study examined bivariate and multivariate relations among anxiety, sensory over-responsivity, and chronic GI problems in a sample of 2,973 children with ASD enrolled in the Autism Treatment Network (ages 2-17 years, 81.6 % male). Twenty-four percent of the sample experienced at least one type of chronic GI problem (constipation, abdominal pain, bloating, diarrhea, and/or nausea lasting three or more months). Children with each type of GI problem had significantly higher rates of both anxiety and sensory over-responsivity. Sensory over-responsivity and anxiety were highly associated, and each provided unique contributions to the prediction of chronic GI problems in logistic regression analyses. The results indicate that anxiety, sensory over-responsivity and GI problems are possibly interrelated phenomenon for children with ASD, and may have common underlying mechanisms. PMID 22850932 [PubMed - as supplied by publisher] Full text: Springer Related CitationsShow all The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. Anxiety disorders and sensory over-responsivity in children with autism spectrum disorders: is there a causal relationship?