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22 août 2012 3 22 /08 /août /2012 09:22
Vitamin B6 suppresses growth of the feline mammary tumor cell line FRM. AuthorsShimada D, et al. Show all Journal Biosci Biotechnol Biochem. 2006 Apr;70(4):1038-40. Affiliation Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan. Abstract Growth of FRM cells was inhibited by the addition of pyridoxine in a dose-dependent manner. Use of 5 mM pyridoxine caused an almost complete arrest of cell growth. Pyridoxal was as effective as pyridoxine, but pyridoxamine showed weak inhibitory action. Electron-microscopic examination of control cells revealed large nuclei and cellular membranes with villi, but, in pyridoxine-treated cells, condensed or degraded nuclei were observed. Many vacuoles and cholesterol crystals were widely distributed inside the cellular membrane of pyridoxine-treated cells. One of the vacuoles was identified as a lipid droplet. The DNA ladder was observed in the pyridoxine-treated cells. It is suggested that pyridoxine treatment of FRM cells causes cytolysis of cells by apoptosis. PMID 16636479 [PubMed - indexed for MEDLINE]

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