22 avril 2012 7 22 /04 /avril /2012 12:10
Nature Reviews Neuroscience 13, 293-307 (May 2012) | doi:10.1038/nrn3229 Impaired mitochondrial function in psychiatric disorders Husseini Manji1, Tadafumi Kato2, Nicholas A. Di Prospero1, Seth Ness1, M. Flint Beal3, Michael Krams1 & Guang Chen1 About the authors top of page Abstract Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent mental illnesses that affect the lives of millions of individuals. Although these disorders have traditionally been viewed as 'neurochemical diseases', it is now clear that they are associated with impairments of synaptic plasticity and cellular resilience. Although most patients with these disorders do not have classic mitochondrial disorders, there is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses. Enhancing mitochondrial function could represent an important avenue for the development of novel therapeutics and also presents an opportunity for a potentially more efficient drug-development process.