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11 avril 2012 3 11 /04 /avril /2012 07:16
Cognitive impairments linked to oxidative stress in psychosis patients MedWire News : Results from a Spanish study suggest that peripheral biomarkers of oxidative stress and inflammation can predict cognitive function in patients with first-episode psychosis (FEP). Writing in Schizophrenia Research , Mónica Martínez-Cengotitabengoa (Santiago Hospital, Vitoria) and team explain that oxidative stress is involved in neurodegeneration and the pathophysiology of neuropsychiatric diseases. More specifically, they note, "inflammatory mediators, such as cytokines, which can tip the redox balance into a pro-oxidant state, are altered in patients with schizophrenia". To investigate the relationship between oxidative stress and neurocognitive deficits in psychosis patients, the team studied 28 FEP patients and 28 age-, gender-, and education-matched mentally healthy individuals (controls). Blood samples were collected from the participants and assessed for total antioxidant status (TAS), superoxide dismutase (SOD), total glutathione (GSH), catalase (CAT), glutathione peroxidase, lipid peroxidation, nitrites, and the chemokine monocyte chemoattractant protein-1 (MCP-1). The participants also underwent comprehensive cognitive assessments of attention, processing speed, working memory, and executive function. In the case of the FEP patients, these assessments were conducted 6 months after starting treatment when all had achieved remission. The researchers found that FEP patients had a significantly lower TAS than controls, as well as significantly lower levels of CAT and glutathione peroxidase, at 2695.15 versus 4262.79 U/mL, and 148.18 versus 329.47 mmol/mL, respectively. There were no significant differences between the groups regarding levels of SOD, GSH, lipid peroxidation, nitrites, and MCP-1, however. In FEP patients, linear regression analysis revealed that there were significant negative associations between MCP-1 levels and learning and memory, after adjustment for atypical antipsychotic use at admission and at the time of cognitive assessment. Furthermore, nitrite levels were significantly and negatively associated with executive function in FEP patients, while glutathione levels were positively associated with executive function. Martínez-Cengotitabengoa and colleagues conclude: "Our results show an association between peripheral inflammatory/oxidative markers and certain cognitive function domains at 6 months after a first psychotic episode." They add: "Further studies of the role of the chemokine MCP-1 in psychosis are warranted." By Mark Cowen 29/03/2012

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mutuelle 06/06/2012 14:33

Pouvez vous nous en dire plus sur le stress oxydatif?