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10 avril 2012 2 10 /04 /avril /2012 13:21
Central nervous system regeneration does not occur L S Illis1 1Willow Pond House, Lymore Valley, Hampshire, UK Abstract Objectives: To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site. Setting: Worldwide. Methods: A search of publications using ‘PubMed’ and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator. Results: There is no evidence for CNS regeneration. Conclusion: A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS. Spinal Cord (2012) 50, 259–263; doi:10.1038/sc.2011.132; published online 22 November 2011 Correspondence: Dr LS Illis, Willow Pond House, Lymore Valley, Milford-On-Sea, Lymington, Hampshire SO41 0TW, UK. E-mail: lee@illis.co.uk Received 6 May 2011; Revised 3 October 2011; Accepted 4 October 2011

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